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| Nomenclature |
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Symbol:
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Ightm3Tim
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Name:
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immunoglobulin heavy chain complex;
targeted mutation 3, Tim Manser
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MGI ID: |
MGI:3609136 |
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Synonyms: |
HK171 |
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Gene:
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Igh
Location:
unknown
Genetic Position: Chr12,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:102308
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed to replace J1 through J4 with a neomycin resistance cassette followed by the 36-65VDJ region with the following amino acid substitutions: A9V, Y32N, I51N, T58I, K59T, S77N, V100E, Y107K, with numbering from the mature amino terminus of the H chain. (J:102308)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Igh Mutation:
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25 strains or lines available |
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| References |
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Original: |
J:102308
Heltemes-Harris L et al.,
"An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion."
Int Immunol 2005 Nov;17(11):1447-61
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All: |
1 reference(s)
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Analysis Tools
