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| Nomenclature |
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Symbol:
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Gadd45btm1Daa
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Name:
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growth arrest and DNA-damage-inducible 45 beta;
targeted mutation 1, Dan A Liebermann
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MGI ID: |
MGI:3608798 |
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Synonyms: |
Gadd45b- |
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Gene:
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Gadd45b
Location:
Chr10:80930091-80932204 bp, + strand
Genetic Position: Chr10,
39.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:102680
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Parent Cell Line:
| ESVJ-1183 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 301 bp of the proximal promoter, the 5' untranslated region of the mRNA, the entire protein coding region and 425 bp of the 3' untranslated region were replaced by a 1.9 kb neo cassette (transcription of neo is antisense) from the plasmid pGT-N29 via homologous recombination. (J:102680)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gadd45b Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:102680
Gupta M et al.,
"Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis."
Oncogene 2005 Nov 3;24(48):7170-9
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All: |
4 reference(s)
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Analysis Tools
