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| Nomenclature |
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Symbol:
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Fut8tm1Nta
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Name:
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fucosyltransferase 8;
targeted mutation 1, Naoyuki Taniguchi
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MGI ID: |
MGI:3608699 |
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Synonyms: |
Fut8- |
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Gene:
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Fut8
Location:
Chr12:77238104-77475996 bp, + strand
Genetic Position: Chr12,
35.46 cM
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Growth retardation in Fut8tm1Nta/Fut8tm1Nta mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:102932
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 2, which contains the translation initiation site, was replaced with an IRES-LacZ-Neo-pA cassette. Northern blot analysis of lung and brain RNA confirmed absence of full-length mRNA. (J:102932)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:102932
Wang X et al.,
"Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice."
Proc Natl Acad Sci U S A 2005 Nov 1;102(44):15791-6
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All: |
6 reference(s)
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Analysis Tools
