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| Nomenclature |
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Symbol:
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Cpt1atm1Pwo
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Name:
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carnitine palmitoyltransferase 1a, liver;
targeted mutation 1, Philip A Wood
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MGI ID: |
MGI:3606251 |
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Synonyms: |
Cpt-1atm1Uab |
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Gene:
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Cpt1a
Location:
Chr19:3323301-3385732 bp, + strand
Genetic Position: Chr19,
3.08 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101934
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A targeting construct was designed to replace exons 11-18 with a neomycin resistance gene in the reverse orientation to transcription. FISH confirmed correct targeting of the locus. (J:101934)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:101934
Nyman LR et al.,
"Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouse."
Mol Genet Metab 2005 Sep-Oct;86(1-2):179-87
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All: |
1 reference(s)
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Analysis Tools
