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| Nomenclature |
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Symbol:
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Mybpc3tm1Lcrr
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Name:
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myosin binding protein C, cardiac;
targeted mutation 1, Lucie Carrier
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MGI ID: |
MGI:3606208 |
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Synonyms: |
cMyBP-c- |
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Gene:
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Mybpc3
Location:
Chr2:91118144-91136516 bp, + strand
Genetic Position: Chr2,
50.44 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101903
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced the transcription initiation site, all of exon 1 and most of exon 2, resulting in complete transcriptional inactivation. (J:101903)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mybpc3 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:101903
Carrier L et al.,
"Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice."
Cardiovasc Res 2004 Aug 1;63(2):293-304
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All: |
4 reference(s)
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Analysis Tools
