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| Nomenclature |
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Symbol:
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Smarca4tm1Pcn
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Name:
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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4;
targeted mutation 1, Pierre Chambon
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MGI ID: |
MGI:3605892 |
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Synonyms: |
Brg1F, brg1FL, Brg1L2, Brg1lox, SNF2BetaL:La |
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Gene:
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Smarca4
Location:
Chr9:21616169-21704217 bp, + strand
Genetic Position: Chr9,
7.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101729
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Parent Cell Line:
| P1 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A single loxP site was inserted upstream of exon 2 and a floxed hygromycin resistance cassette was inserted in intron 3. The hygromycin resistance cassette was then selectively excised from correctly targeted ES cells by transient transfection with a cre-expression vector. Exons 2 and 3 were flanked by loxP sites in the resulting ES cells. Heterozygous and homozygous mice carrying this gene in the germline were indistinguishable from wild-type mice. (J:42997, J:101729)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:101729
Indra AK et al.,
"Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation."
Development 2005 Oct;132(20):4533-44
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All: |
20 reference(s)
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Analysis Tools
