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| Nomenclature |
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Symbol:
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Adamts13tm1Dgi
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Name:
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a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13;
targeted mutation 1, David Ginsburg
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MGI ID: |
MGI:3605825 |
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Synonyms: |
Adamts13- |
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Gene:
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Adamts13
Location:
Chr2:26973416-27009628 bp, + strand
Genetic Position: Chr2,
19.14 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101752
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced exons 1-6. RT-PCR of mutant liver samples confirmed absence of transcript. (J:101752)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:101752
Motto DG et al.,
"Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice."
J Clin Invest 2005 Oct;115(10):2752-61
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All: |
16 reference(s)
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Analysis Tools
