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| Nomenclature |
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Symbol:
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Tg(Prnp-MAPT*P301L)JNPL3Hlmc
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Name:
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transgene insertion JNPL3, Mike Hutton
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MGI ID: |
MGI:3604148 |
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Synonyms: |
JNPL3, P301L, P301L tau 4R, tauP301L, tau (P301L), Tg(Prnp-MAPT*P301L)3Hlmc |
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Transgene:
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Tg(Prnp-MAPT*P301L)JNPL3Hlmc
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse prion protein promoter was used to drive expression of human microtubule-associated protein tau with a P301L substitution. Hemizygous mice mice expressed the protein at levels roughly equivalent to that of endogenous tau. A largely neuronal expression pattern was shown by in situ hybridization, with strongest signals in the cerebellum and hippocampus, followed by the thalamus, hypothalamus, spinal cord, brainstem and cortex. (J:63887)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Microinjected into fertilized mouse C57BL/DBA2/SW eggs.
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| References |
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Original: |
J:63887
Lewis J et al.,
"Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein."
Nat Genet 2000 Aug;25(4):402-5
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All: |
28 reference(s)
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Analysis Tools
