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| Nomenclature |
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Symbol:
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Fgfr2tm2Cxd
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Name:
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fibroblast growth factor receptor 2;
targeted mutation 2, Chu-Xia Deng
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MGI ID: |
MGI:3604072 |
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Synonyms: |
Fgfr2neo250 |
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Gene:
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Fgfr2
Location:
Chr7:130162451-133123350 bp, - strand
Genetic Position: Chr7,
73.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101385
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: A targeting vector containing a GG substitution resulted in a Ser250Trp mutation in exon 7. A floxed neo was inserted upstream of exon 7. This allele was a hypomorph, expressed only in significantly reduced levels. Removal of the floxed neo restores expression levels. (J:101385)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgfr2 Mutation:
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18 strains or lines available |
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| References |
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Original: |
J:101385
Chen L et al.,
"A Ser250Trp substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis."
Bone 2003 Aug;33(2):169-78
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All: |
1 reference(s)
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Analysis Tools
