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| Nomenclature |
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Symbol:
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Smarcb1tm1Gvk
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Name:
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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1;
targeted mutation 1, Ganjam V Kalpana
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MGI ID: |
MGI:3603561 |
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Synonyms: |
Ini1delta6,7 |
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Gene:
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Smarcb1
Location:
Chr10:75896769-75921617 bp, - strand
Genetic Position: Chr10,
38.61 cM
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Smarcb1tm1Gvk/Smarcb1+ mice develop tumors that overexpress Cyclin D1
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101185
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Parent Cell Line:
| WW6 (ES Cell) |
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Strain of Origin:
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STOCK 129/Sv and C57BL/6J and SJL
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 6 and 7 were replaced with a PGK-hygromycin resistance cassette. Immunoblot of total protein from heterozygous mice failed to detect a truncated protein corresponding to the mutant allele, thereby indicating it is most likely a null. (J:101185)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Smarcb1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:101185
Tsikitis M et al.,
"Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss."
Proc Natl Acad Sci U S A 2005 Aug 23;102(34):12129-34
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All: |
2 reference(s)
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Analysis Tools
