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| Nomenclature |
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Symbol:
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Insig2tm1Mbjg
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Name:
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insulin induced gene 2;
targeted mutation 1, Joseph L Goldstein
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MGI ID: |
MGI:3603525 |
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Synonyms: |
Insig-2-, Insig2-, Insig2tm1Jlg |
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Gene:
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Insig2
Location:
Chr1:121304353-121332589 bp, - strand
Genetic Position: Chr1,
52.91 cM, cytoband E2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101203
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A polIIsneopA cassette was inserted to replace exons 2 and 3, which encode the first 123 of 225 amino acids. Northern blot and immunoblot failed to detect wild-type transcript and protein, respectively. An aberrant transcript was detected, possibly due to an initiation site in exons 1a or 1b and splicing directly to exon 4, 5 or 6. In such a transcript, the first available start codon is in exon 5, and, if translated, this transcript would yield a 23 amino-acid peptide. (J:101203)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:101203
Engelking LJ et al.,
"Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins."
J Clin Invest 2005 Sep;115(9):2489-98
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All: |
3 reference(s)
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Analysis Tools
