|
|
| Nomenclature |
|
Symbol:
|
Insig1tm1Mbjg
|
|
Name:
|
insulin induced gene 1;
targeted mutation 1, Joseph L Goldstein
|
|
MGI ID: |
MGI:3603523 |
|
Synonyms: |
Insig1f, Insig1tm1Jlg |
|
Gene:
|
Insig1
Location:
Chr5:28071363-28078662 bp, + strand
Genetic Position: Chr5,
13.94 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:101203
|
|
Parent Cell Line:
| SM1 (ES Cell) |
|
Strain of Origin:
|
129S6/SvEvTac
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Floxed/Frt) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A vector was designed to flank exon 1, containing the ATG, with loxP sites. An FRT and floxed neo was inserted upstream of the exon. Transcript was reduced by 20%, possibly due to transcriptional interference from the neo cassette. (J:101203)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:101203
Engelking LJ et al.,
"Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins."
J Clin Invest 2005 Sep;115(9):2489-98
|
|
All: |
2 reference(s)
|
|
Analysis Tools
