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| Nomenclature |
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Symbol:
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Fmr1tm1Cidz
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Name:
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fragile X mental retardation syndrome 1;
targeted mutation 1, C I De Zeeuw
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MGI ID: |
MGI:3603442 |
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Synonyms: |
Fmr1 CKO |
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Gene:
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Fmr1
Location:
ChrX:68678541-68717963 bp, + strand
Genetic Position: ChrX,
34.83 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101021
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: The first coding exon was left flanked with loxP sites upon removal of a floxed neomycin resistance cassette. (J:101021, J:108008)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fmr1 Mutation:
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21 strains or lines available |
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| References |
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Original: |
J:101021
Koekkoek SK et al.,
"Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome."
Neuron 2005 Aug 4;47(3):339-52
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All: |
4 reference(s)
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Analysis Tools
