|
|
| Nomenclature |
|
Symbol:
|
Thratm3Ven
|
|
Name:
|
thyroid hormone receptor alpha;
targeted mutation 3, Bjorn Vennstrom
|
|
MGI ID: |
MGI:3603303 |
|
Synonyms: |
Tralpha1R384C, TRalpham |
|
Gene:
|
Thra
Location:
Chr11:98740638-98769006 bp, + strand
Genetic Position: Chr11,
62.58 cM, cytoband D-E
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:100290
|
|
Parent Cell Line:
| E14 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A targeting vector was designed to introduce an Arg384Cys substitution into helix 12 of the C-terminal region. (J:100290)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Thra Mutation:
|
14 strains or lines available |
|
| References |
|
Original: |
J:100290
Tinnikov A et al.,
"Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1."
EMBO J 2002 Oct 1;21(19):5079-87
|
|
All: |
11 reference(s)
|
|
Analysis Tools
