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| Nomenclature |
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Symbol:
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Errfi1tm1Gvw
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Name:
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ERBB receptor feedback inhibitor 1;
targeted mutation 1, George F Vande Woude
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MGI ID: |
MGI:3603195 |
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Synonyms: |
Mig-6- |
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Gene:
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Errfi1
Location:
Chr4:150853919-150868892 bp, + strand
Genetic Position: Chr4,
81.5 cM, cytoband E1
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Errfi1tm1Gvw/Errfi1tm1Gvw mouse joints display pathological features of osteoarthritis
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:100927
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The entire coding region (exons 2-4) were replaced with a pgk-neomycin resistance gene. Absence of transcript was demonstrated in Northern blot of mutant liver and thymus. (J:100927)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Errfi1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:100927
Zhang YW et al.,
"Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease."
Proc Natl Acad Sci U S A 2005 Aug 16;102(33):11740-5
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All: |
2 reference(s)
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Analysis Tools
