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| Nomenclature |
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Symbol:
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Spred2Gt(XB228)Byg
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Name:
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sprouty-related, EVH1 domain containing 2;
gene trap XB228, BayGenomics
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MGI ID: |
MGI:3590299 |
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Synonyms: |
Spred-2-, Spred2Gt(pGTO)1Ksch |
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Gene:
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Spred2
Location:
Chr11:19924375-20024026 bp, + strand
Genetic Position: Chr11,
12.79 cM, cytoband A3.2
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Achondroplasia-like dwarfism in Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Mutant Cell Line:
| XB228 (BayGenomics) |
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Germline Transmission:
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Earliest citation of germline transmission:
J:100826
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Gene trapped |
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Mutation: | |
Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap |
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Mutation details: A gene trap vector, pGT)pfs, containing a splice acceptor, Betageo and SV40 pA sequence inserted into intron 4 of the locus. RT-PCR failed to detect transcript in all tissues tested. Northern blot and Western blot confirmed lack of all forms of transcript and protein in mutant brain samples, respectively. (J:100826)
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Sequence Tags: |
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Sequence tag details (1 tag)
| Tag ID | GenBank ID | Method |
Tag Location (trapped strand)* | Select |
* GRCm38
(strand of gene trap mutagenesis) |
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Genome Context: |
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Genome Browser view of this mutation
Blue line marks
approximate position of gene trap insertion
287 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
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| References |
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Original: |
J:100826
Bundschu K et al.,
"Gene disruption of Spred-2 causes dwarfism."
J Biol Chem 2005 Aug 5;280(31):28572-80
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All: |
5 reference(s)
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Analysis Tools
