Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
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Name:
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transgene insertion 1, John F Elliott
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MGI ID: |
MGI:3590082 |
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Synonyms: |
DQ8+, human CD4, DQ8 transgene, human CD4, DQA1*0301, DQB1*0302 transgene, Tg(CD2-CD4,HLA-DQA1*0301,HLA-DQB1*0302)1Ell, Tg(CD4,HLA-DQ8)1Ell |
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Transgene:
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Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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NOD/MrkTac
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Fertilized oocytes were co-injected with two DNA fragments: a human CD4 cDNA joined to the promoter from the human CD2 gene and a large DNA fragment, reassembled from segments of the cosmid pDCbeta2, containing the human major histocompatibility (MHC) class II alleles HLA-DQA1*0301 and HLA-DQB*0302, which together encode the dimer comprising the HLA-DQ8 molecule, plus 5' regulatory elements. Human CD4 is expressed at a low level on all T cells of transgenic mice. HLA-DQ8 is expressed in homozygous NOD mice at a level comparable to that of the endogenous NOD H2-Abetag7 MHC class II molecule in wild-type NOD mice. (J:87013, J:113267)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Although in NOD mice homozygous for this transgene alone endogeous NOD H2-Abetag7 and transgene-derived HLA-DQ8 are expressed at similar levels, virtually all CD4+ T-cell responses are H2Abeta1g7 restricted (J:87013).
Phenotypic Similarity to Human Syndrome: Idiopathic Dilated Cardiomyopathy in double homozygous mice of the strain NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell (J:86540)
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| References |
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Original: |
J:87013
Liu J et al.,
"Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice."
Diabetes 1999 Mar;48(3):469-77
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All: |
3 reference(s)
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Analysis Tools
