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| Nomenclature |
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Symbol:
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Trp53tm1Thl
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Name:
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transformation related protein 53;
targeted mutation 1, Thomas Ludwig
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MGI ID: |
MGI:3589921 |
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Synonyms: |
p53flex7, Trp53loxP, Trp53tm1Ppp |
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Gene:
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Trp53
Location:
Chr11:69580359-69591873 bp, + strand
Genetic Position: Chr11,
42.83 cM, cytoband B2-C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:100683
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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A targeting construct was designed to insert loxP sites to flank exon 7. (J:100683)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Glioblastoma J:172585.
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| References |
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Original: |
J:100683
Chen Z et al.,
"Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis."
Nature 2005 Aug 4;436(7051):725-30
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All: |
4 reference(s)
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Analysis Tools
