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| Nomenclature |
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Symbol:
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Tg(PRNP-APPSweInd)8Dwst
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Name:
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transgene insertion 8, David Westaway
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MGI ID: |
MGI:3589475 |
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Synonyms: |
APP-KM670/671NL+V717F, CRND8, Tg19959, Tg(APPSwInd)8Dwst, TgCRND8 |
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Transgene:
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Tg(PRNP-APPSweInd)8Dwst
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C3H/HeJ x C57BL/6J)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene expresses the mutant human amyloid protein precursor APPSweInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the Syrian hamster prion protein promoter. Transgenic mice express the App protein in brain at approximately 5 times the level of control mice. High level production of the pathogenic Abeta42 form of the Abeta peptide is seen by three months of age. (J:69967)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:69967
Chishti MA et al.,
"Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695."
J Biol Chem 2001 Jun 15;276(24):21562-70
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All: |
76 reference(s)
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Analysis Tools
