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| Nomenclature |
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Symbol:
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Tg(HLA-DQA1,HLA-DQB1)1Dv
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Name:
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transgene insertion 1, Chella David
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MGI ID: |
MGI:3586633 |
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Synonyms: |
Abeta0.DQ8, DQ8, HLA-DQ8, HLA-DQ8 Tg, HLA-DQA1*0301/DQB1*0302, Tg(HLA-DQA1*301,HLA-DQB1*302)1Dv |
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Transgene:
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Tg(HLA-DQA1,HLA-DQB1)1Dv
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(CBA/J x B10.M-H2f)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A 30-kb human genomic DNA fragment containing the entire HLA-DQA1*0301 gene and a promoter-truncated HLA-DQB1*0302 gene from cosmid H11A and a 38-kb DNA fragment containing the entire HLA-DQB1*0302 gene from cosmid X10A were coinjected. (J:88296)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Flow cytometric analysis of peripheral blood leukocytes (PBL) using a monoclonal antibody to HLA-DQ demonstrated that transgenic mice express the transgenes. 25-40% of the PBLs of mixed-background transgenic mice homozygous for the targeted MHC class II mutation H2-Ab1tm1Dim express the transgenes. Lymph nodes of such mice contain three-fold the levels of CD4+ CD44+ T-cells as do those of nontransgenic MHC class II-deficient mice, levels similar to those of class II-sufficient mice. Immunization of transgenic H2-Ab1tm1Dim homozygous mice with bovine collagen II results in a strong IgG antibody response to the immunogen, and 66% of these mice develop severe, persistent arthritis. (J:88296)
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| References |
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Original: |
J:88296
Nabozny GH et al.,
"HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis."
J Exp Med 1996 Jan 1;183(1):27-37
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All: |
53 reference(s)
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Analysis Tools
