|
|
| Nomenclature |
|
Symbol:
|
Park7tm1Xz
|
|
Name:
|
Parkinson disease (autosomal recessive, early onset) 7;
targeted mutation 1, Xiaoxi Zhuang
|
|
MGI ID: |
MGI:3586448 |
|
Synonyms: |
DJ-1- |
|
Gene:
|
Park7
Location:
Chr4:150897133-150914437 bp, - strand
Genetic Position: Chr4,
81.52 cM, cytoband E1
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:99905
|
|
Parent Cell Line:
| E14TG2a.4 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A PGK-neo cassette flanked by FRT sites replaced the first five exons and part of the promoter. RT-PCR confirmed absence of transcript in mutant skin fibroblasts. (J:99905)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Park7 Mutation:
|
39 strains or lines available |
|
| References |
|
Original: |
J:99905
Chen L et al.,
"Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice."
J Biol Chem 2005 Jun 3;280(22):21418-26
|
|
All: |
4 reference(s)
|
|
Analysis Tools
