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| Nomenclature |
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Symbol:
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Man2b1tm1Psa
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Name:
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mannosidase 2, alpha B1;
targeted mutation 1, Paul Saftig
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MGI ID: |
MGI:3584185 |
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Synonyms: |
alpha-Man- |
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Gene:
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Man2b1
Location:
Chr8:85083269-85098739 bp, + strand
Genetic Position: Chr8,
41.55 cM, cytoband C2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:56659
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance gene was inserted into exon 2, resulting in a premature stop codon in the ORF. The complete absence of transcript in mutants was confirmed by Northern blot and RT-PCR analyses. (J:56659)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Man2b1 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:56659
Stinchi S et al.,
"Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis."
Hum Mol Genet 1999 Aug;8(8):1365-72
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All: |
3 reference(s)
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Analysis Tools
