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| Nomenclature |
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Symbol:
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Spry2tm1Ayos
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Name:
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sprouty homolog 2 (Drosophila);
targeted mutation 1, Akihiko Yoshimura
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MGI ID: |
MGI:3584128 |
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Synonyms: |
Sprouty2- |
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Gene:
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Spry2
Location:
Chr14:105891949-105896819 bp, - strand
Genetic Position: Chr14,
56.16 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:99827
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced most of exon 2. RT-PCR failed to detect transcript and protein was absent in Western blot of mutant MEFs. (J:99827)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Spry2 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:99827
Taketomi T et al.,
"Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia."
Nat Neurosci 2005 Jul;8(7):855-7
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All: |
5 reference(s)
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Analysis Tools
