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| Nomenclature |
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Symbol:
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Tg(UAS-Smo*W539L)1Amc
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Name:
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transgene insertion 1, Andrew P McMahon
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MGI ID: |
MGI:3584023 |
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Synonyms: |
UAS-Smo* |
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Transgene:
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Tg(UAS-Smo*W539L)1Amc
Location:
unknown
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains five upstream activating sequence (UAS) elements, a Wnt1 promoter, the rat Smo cDNA containing a W539L mutation, the human placental alkaline phosphatase cDNA under the control of an internal ribosomal entry site, lacZ, and a poly A signal from the murine Wnt1 gene. UAS elements drive the expression of the mutated ligand-independent activated rat Smo gene. Expression of this transgene is dependent on GAL4 expression. (J:73071)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:73071
Long F et al.,
"Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation."
Development 2001 Dec;128(24):5099-108
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All: |
1 reference(s)
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Analysis Tools
