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| Nomenclature |
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Symbol:
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Polhtm1Fmh
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Name:
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polymerase (DNA directed), eta (RAD 30 related);
targeted mutation 1, Fumio Hanaoka
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MGI ID: |
MGI:3583930 |
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Gene:
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Polh
Location:
Chr17:46172004-46202625 bp, - strand
Genetic Position: Chr17,
22.9 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:99721
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 8 and gives rise to a stop codon within the neomycin gene, truncating any potential protein product before the pol catalytic domains. Western blot analysis failed to detect truncated protein. (J:99721)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Polh Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:99721
Martomo SA et al.,
"Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification."
Proc Natl Acad Sci U S A 2005 Jun 14;102(24):8656-61
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All: |
3 reference(s)
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Analysis Tools
