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| Nomenclature |
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Symbol:
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Myctm1Lbox
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Name:
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myelocytomatosis oncogene;
targeted mutation 1, Linda M Boxer
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MGI ID: |
MGI:3583919 |
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Synonyms: |
IgH-3'E-myc |
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Gene:
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Myc
Location:
Chr15:61985391-61990374 bp, + strand
Genetic Position: Chr15,
26.19 cM, cytoband D2-D3
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Histopathological analysis of lymphomas in Myctm1Lbox/Myctm1Lbox and Myctm1Lbox/Myc+ mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:97900
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The IgH 3' enhancers SH1234 were inserted upstream of the locus. RT-PCR of mutants demonstrated elevated transcript levels in spleenic B-lymphocytes, but normal levels in brain, liver, kidney, lung and thymus. (J:97900)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Myc Mutation:
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24 strains or lines available |
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| References |
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Original: |
J:97900
Wang J et al.,
"Regulatory elements in the immunoglobulin heavy chain gene 3'-enhancers induce c-myc deregulation and lymphomagenesis in murine B cells."
J Biol Chem 2005 Apr 1;280(13):12766-73
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All: |
1 reference(s)
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Analysis Tools
