Rbpjtm1Hon
Targeted Allele Detail
|
|
| Nomenclature |
|
Symbol:
|
Rbpjtm1Hon
|
|
Name:
|
recombination signal binding protein for immunoglobulin kappa J region;
targeted mutation 1, Tasuku Honjo
|
|
MGI ID: |
MGI:3583755 |
|
Synonyms: |
RBPf, RBP-JC, RBP-Jf, Rbpjflox, Rbp-Jflox, RBP-JkappaFl, RBP-Jkappaflox, RBPJkappaloxP, RBP-Jlox, RbpjloxP, Rbpsuhtm3Kyo |
|
Gene:
|
Rbpj
Location:
Chr5:53590215-53657445 bp, + strand
Genetic Position: Chr5,
29.37 cM, cytoband C1-C3
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:99747
|
|
Parent Cell Line:
| E14 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Floxed/Frt) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: LoxP sites were inserted to flank exon 6, which encodes the DNA binding domain, and exon 7. In addition, a neomycin resistance gene was inserted between exon 7 and the 3' loxP site. (J:99747)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:99747
Han H et al.,
"Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision."
Int Immunol 2002 Jun;14(6):637-45
|
|
All: |
130 reference(s)
|
|
|
Analysis Tools
