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| Nomenclature |
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Symbol:
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Krastm1Bbd
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Name:
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v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog;
targeted mutation 1, Mariano Barbacid
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MGI ID: |
MGI:3582830 |
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Synonyms: |
KrasG12V, KrasLSLG12Vgeo, K-rasV12 |
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Gene:
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Kras
Location:
Chr6:145216699-145250239 bp, - strand
Genetic Position: Chr6,
77.37 cM, cytoband G2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:86101
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: In one homologous recombination event an IRES Beta-geo cassette was inserted into the 3' untranslated region and in a second homologous recombination event a mutation changing codon 12 in exon 1 into a valine was inserted along with a floxed transcriptional stop and PGK-Hydro cassette. This resulted in bicistronic Cre recombination-dependent expression of the oncogenic Kras allele and Beta-geo. (J:86101)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:86101
Guerra C et al.,
"Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context."
Cancer Cell 2003 Aug;4(2):111-20
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All: |
19 reference(s)
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Analysis Tools
