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| Nomenclature |
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Symbol:
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Tg(BCR/ABL)623Hkp
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Name:
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transgene insertion 623, Nora Heisterkamp
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MGI ID: |
MGI:3582388 |
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Synonyms: |
BCR-ABL1, P190 BCR-ABL, P190 BCR/ABL |
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Transgene:
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Tg(BCR/ABL)623Hkp
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse metallothionein-1 promoter drives expression of the human p190 BCR/ABL fusion gene that has the ABL oncogene fused head to tail with the 5' exons of the BCR gene with the break occurring in the first intron. This fusion gene produces the p190 protein with abnormal tyrosin kinase activity. Founder 623 was used to generate the transgenic line. (J:91174)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:89786
Voncken JW et al.,
"Restricted oncogenicity of BCR/ABL p190 in transgenic mice."
Cancer Res 1992 Aug 15;52(16):4534-9
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All: |
15 reference(s)
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Analysis Tools
