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| Nomenclature |
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Symbol:
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Oas1dtm1Zuk
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Name:
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2'-5' oligoadenylate synthetase 1D;
targeted mutation 1, Martin M Matzuk
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MGI ID: |
MGI:3581976 |
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Synonyms: |
Oas1d- |
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Gene:
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Oas1d
Location:
Chr5:120914536-120921652 bp, + strand
Genetic Position: Chr5,
60.87 cM, cytoband F
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:99134
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A targeting vector was designed to replace exon 1 and part of exon 2, sequence encompassing the transcription start site, translation start site and 157 codons, with a PGK-hprt cassette. Immunohistochemsitry and Western blot analyses confirmed absence of protein in mutant ovaries. (J:99134)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Oas1d Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:99134
Yan W et al.,
"Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility."
Mol Cell Biol 2005 Jun;25(11):4615-24
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All: |
1 reference(s)
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Analysis Tools
