|
|
| Nomenclature |
|
Symbol:
|
Ppargtm1Lja
|
|
Name:
|
peroxisome proliferator activated receptor gamma;
targeted mutation 1, J Larry Jameson
|
|
MGI ID: |
MGI:3580102 |
|
Synonyms: |
PPARKI |
|
Gene:
|
Pparg
Location:
Chr6:115361221-115490401 bp, + strand
Genetic Position: Chr6,
53.41 cM, cytoband E3-F1
|
|
Embryonic lethality of Ppargtm1Lja/Ppargtm1Lja mice
Show the 3 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:98786
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Nucleotide substitutions |
| |
|
Mutation details: The leucine residue at codon 466 was changed to alanine due to a CCT to AGC substitution. RT-PCR confirmed equivalent expression of mutant and wild-type alleles. (J:98786)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Pparg Mutation:
|
11 strains or lines available |
|
| References |
|
Original: |
J:98786
Freedman BD et al.,
"A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome."
J Biol Chem 2005 Apr 29;280(17):17118-25
|
|
All: |
1 reference(s)
|
|
Analysis Tools
