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| Nomenclature |
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Symbol:
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Prkar1atm1.1Lsk
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Name:
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protein kinase, cAMP dependent regulatory, type I, alpha;
targeted mutation 1.1, Lawrence S Kirschner
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MGI ID: |
MGI:3580100 |
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Synonyms: |
Prkar1a-, Prkar1adelta2 |
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Gene:
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Prkar1a
Location:
Chr11:109649405-109669656 bp, + strand
Genetic Position: Chr11,
72.33 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:98799
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site was inserted between exons 1b and 1c and a floxed neomycin resistance cassette was inserted in intron 2. Mice carrying the floxed neomycin resistance cassette were bred to EIIa-cre mice, resulting in removal of the sequences located between exons 1b and 1c and in intron 2. Western blot showed complete absence of protein in mutant mice. (J:98799)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Prkar1a Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:98799
Kirschner LS et al.,
"A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues."
Cancer Res 2005 Jun 1;65(11):4506-14
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All: |
7 reference(s)
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Analysis Tools
