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| Nomenclature |
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Symbol:
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Tbx20tm1.1Rph
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Name:
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T-box 20;
targeted mutation 1.1, Richard P Harvey
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MGI ID: |
MGI:3579836 |
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Synonyms: |
Tbx20lacZ |
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Gene:
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Tbx20
Location:
Chr9:24720812-24774303 bp, - strand
Genetic Position: Chr9,
10.25 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:98489
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Cre-mediated recombination resulted in the excision of the coding sequence in exons 1-3, and the placement of a lacZ reporter gene into endogenous cis-regulatory elements. RT-PCR confirmed absence of exons 1-3 and preservation of exons 4-6. (J:98489)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tbx20 Mutation:
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3 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Dilated Cardiomyopathy is seen in heterozygotes (J:98489)
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| References |
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Original: |
J:98489
Stennard FA et al.,
"Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation."
Development 2005 May;132(10):2451-62
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All: |
2 reference(s)
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Analysis Tools
