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| Nomenclature |
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Symbol:
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Axin2tm1Wbm
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Name:
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axin2;
targeted mutation 1, Walter Birchmeier
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MGI ID: |
MGI:3579503 |
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Synonyms: |
Ax2-, Axin2-, Axin2lacZ, Axin2lacZki, Axin2NLSlacZ, Axin2tm1Jbeh, conductinlacZ, Conductinlz |
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Gene:
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Axin2
Location:
Chr11:108920349-108950783 bp, + strand
Genetic Position: Chr11,
71.83 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:74286
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A lacZ gene containing a nuclear localization signal was introduced in frame to the endogenous start codon by homologous recombination, thereby replacing most of exon 2. Beta-galactosidase staining reflected endogenous gene expression in the developing embryo. (J:74286)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:74286
Lustig B et al.,
"Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors."
Mol Cell Biol 2002 Feb;22(4):1184-93
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All: |
53 reference(s)
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Analysis Tools
