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| Nomenclature |
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Symbol:
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Gabrg2tm2Geh
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Name:
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gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2;
targeted mutation 2, Gregg E Homanics
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MGI ID: |
MGI:3579440 |
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Gene:
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Gabrg2
Location:
Chr11:41910203-42000857 bp, - strand
Genetic Position: Chr11,
24.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:98560
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was constructed to flank exon 8 with loxP sites. A neomycin selection cassette was placed downstream of exon 8, within the floxed sequence. Gene expression was demonstrated to be highly variable, ranging from 10-95% of normal, with the average reduction being 65%. Immunohistochemical analysis demonstrated that protein levels were variably reduced. (J:98560)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gabrg2 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:98560
Chandra D et al.,
"GABAA receptor gamma2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines."
BMC Neurosci 2005 Apr 25;6(1):30
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All: |
1 reference(s)
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Analysis Tools
