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| Nomenclature |
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Symbol:
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Park7tm1Shn
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Name:
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Parkinson disease (autosomal recessive, early onset) 7;
targeted mutation 1, Jie Shen
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MGI ID: |
MGI:3579140 |
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Synonyms: |
DJ-1- |
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Gene:
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Park7
Location:
Chr4:150897133-150914437 bp, - strand
Genetic Position: Chr4,
81.52 cM, cytoband E1
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Characterization of Park7tm1Shn/Park7tm1Shn mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:98436
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Parent Cell Line:
| MKV6.5 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Exon 2 was replaced with a pgk-neo cassette. Western blot failed to detect protein in mutant mice. (J:98436)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:98436
Goldberg MS et al.,
"Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1."
Neuron 2005 Feb 17;45(4):489-96
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All: |
11 reference(s)
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Analysis Tools
