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| Nomenclature |
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Symbol:
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Id4tm1Fsky
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Name:
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inhibitor of DNA binding 4;
targeted mutation 1, Fred Sablitzky
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MGI ID: |
MGI:3579084 |
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Synonyms: |
Id4-, Id4/lacZ |
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Gene:
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Id4
Location:
Chr13:48261427-48264036 bp, + strand
Genetic Position: Chr13,
24.71 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:98270
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A lacZ-neo cassette replaced sequence encoding HLH domain and most of the C-temrinus of the gene. The cassette was inserted in-frame, allowing the expression of a fusion gene encoding the N-terminal 65 amino acids of Id4 fused to beta-galactosidase. RT-PCR of mutant brain and testis failed to detect mRNA encoding the HLH domain. X-gal staining demonstrated that expression of the fusion gene was similar to expression of the endogenous gene expression (J:98270)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:98270
Bedford L et al.,
"Id4 is required for the correct timing of neural differentiation."
Dev Biol 2005 Apr 15;280(2):386-95
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All: |
5 reference(s)
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Analysis Tools
