|
|
| Nomenclature |
|
Symbol:
|
Celsr3tm1Agof
|
|
Name:
|
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila);
targeted mutation 1, Andre M Goffinet
|
|
MGI ID: |
MGI:3578665 |
|
Gene:
|
Celsr3
Location:
Chr9:108826320-108852963 bp, + strand
Genetic Position: Chr9,
59.63 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:98367
|
|
Parent Cell Line:
| E14 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Intragenic deletion |
| |
|
Mutation details: A targeting vector was designed to delete exons 19-27. Transcript levels were two- to fourfold lower in mutants than in wild-type animals. RT-PCR confirmed deletion of exons 19-27. A cryptic splice acceptor site in modified intron 27 resulted in an 87-nt 5' extension of exon 28. The resulting protein lacks the GPS, 7TM and C-terminal cytoplasmic sequences. (J:98367)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Celsr3 Mutation:
|
2 strains or lines available |
|
| References |
|
Original: |
J:98367
Tissir F et al.,
"Protocadherin Celsr3 is crucial in axonal tract development."
Nat Neurosci 2005 Apr;8(4):451-7
|
|
All: |
6 reference(s)
|
|
Analysis Tools
