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| Nomenclature |
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Symbol:
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Tg(Igh-VB1-8/Igh-6m)1Mjsk
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Name:
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transgene insertion 1, Mark J Shlomchik
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MGI ID: |
MGI:3578639 |
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Synonyms: |
mIg, Tg(Igh-VB1-8/Igh-6)1Mjsk |
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Transgene:
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Tg(Igh-VB1-8/Igh-6m)1Mjsk
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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NOD/Caj
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene encodes a membrane-bound, but not a secreted, immunoglobulin mu heavy chain. The variable region of the transgene comprises the VDJ moiety from the functionally rearranged Igh gene of the C57BL/6-derived B1-8 hybridoma, containing the V-region segment Vh186.2 and recognizing the hapten (4-hydroxy-3-nitrophenyl)acetyl. This is followed by a J-C intron fragment containing the Igh intronic enhancer and an Igh-6 constant region gene (of haplotype a) from which the exon encoding the secreted form of Igmu and its associated polyadenylation signal have been deleted. (J:55066)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:55066
Chan OT et al.,
"A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus."
J Exp Med 1999 May 17;189(10):1639-48
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All: |
14 reference(s)
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Analysis Tools
