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| Nomenclature |
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Symbol:
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Pou5f1tm1Scho
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Name:
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POU domain, class 5, transcription factor 1;
targeted mutation 1, Hans R Shoeler
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MGI ID: |
MGI:3578312 |
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Synonyms: |
Oct4flox |
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Gene:
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Pou5f1
Location:
Chr17:35506037-35510776 bp, + strand
Genetic Position: Chr17,
18.69 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:95317
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: One loxP site was inserted upstream of exon1 and the essential promoter. A floxed neo cassette was inserted into intron 1. The selection cassette was excised by subsequent transient transcription of Cre recombinase in the ES cells. Northern blot analysis demonstrated that a normal sized transcript was expressed from this allele. (J:95317)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pou5f1 Mutation:
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64 strains or lines available |
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| References |
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Original: |
J:95317
Kehler J et al.,
"Oct4 is required for primordial germ cell survival."
EMBO Rep 2004 Nov;5(11):1078-83
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All: |
5 reference(s)
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Analysis Tools
