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| Nomenclature |
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Symbol:
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Tg(Gdf5-cre-ALPP)1Kng
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Name:
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transgene insertion 1, David M Kingsley
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MGI ID: |
MGI:3577961 |
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Synonyms: |
CAG(A), Gdf5-Cre |
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Transgene:
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Tg(Gdf5-cre-ALPP)1Kng
Location:
unknown
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Joint defects in Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr Tg(Gdf5-cre-ALPP)1Kng/0 mice
Show the 2 image(s) involving this allele.
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains Cre recombinase and human placental alkaline phosphatase under the control of Gdf5 promoter and enhancer elements. A BAC containing the Gdf5 locus was modified by the insertion of a cre-IRES-ALPP into the translational start site to create the transgene. Gdf5 drives expression in developing joints. This line represents three that were created. (J:97780)
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Recombinase activity
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Driver:
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Gdf5
Summary of all recombinase alleles
driven by Gdf5.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:97780
Rountree RB et al.,
"BMP receptor signaling is required for postnatal maintenance of articular cartilage."
PLoS Biol 2004 Nov;2(11):e355
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All: |
8 reference(s)
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Analysis Tools
