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| Nomenclature |
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Symbol:
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Abca1tm1Jp
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Name:
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ATP-binding cassette, sub-family A (ABC1), member 1;
targeted mutation 1, John S Parks
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MGI ID: |
MGI:3577723 |
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Synonyms: |
Abca1fl, Abca1flox |
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Gene:
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Abca1
Location:
Chr4:53030787-53159895 bp, - strand
Genetic Position: Chr4,
28.57 cM, cytoband A5-B3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:98093
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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LoxP sites were inserted to flank exons 45 and 46, which encode the second nucleotide-binding fold. (J:98093)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:98093
Timmins JM et al.,
"Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I."
J Clin Invest 2005 May 2;115(5):1333-1342
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All: |
16 reference(s)
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Analysis Tools
