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| Nomenclature |
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Symbol:
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Drd2tm1Mok
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Name:
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dopamine receptor D2;
targeted mutation 1, Motoya Katsuki
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MGI ID: |
MGI:3576789 |
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Synonyms: |
D2KO |
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Gene:
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Drd2
Location:
Chr9:49340662-49407214 bp, + strand
Genetic Position: Chr9,
26.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:97838
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The 3' end of exon 2, containing the ATG, was replaced by a neomycin resistance gene to prevent production of either of two possible isoforms. In situ hybridization demonstrated no expression of mRNA in mutant brain samples. (J:97838)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:97838
Yamaguchi H et al.,
"Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary."
Genes Cells 1996 Feb;1(2):253-68
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All: |
4 reference(s)
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Analysis Tools
