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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1(Smo/EYFP)Amc
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, Andrew P McMahon
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MGI ID: |
MGI:3576373 |
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Synonyms: |
Gt(ROSA)26Sortm1(smo/YFP)Amc, R26-lsl-SmoM2, R26SmoM2, R26SmoM2, SmoM2, SmoM2fl, SmoM2/Yfp, SmoM2-YFPfl, SmoOEX |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89445
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Parent Cell Line:
| AV3 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A loxP flanked PGK-neo-stop cassette upstream of the Yellow Fluorescent Protein/Smoothened homolog (Drosophila) fusion gene (Smo/EYFP) was inserted into the Gt(ROSA)26Sor locus. The mutant allele consists of a fusion product involving Yellow Fluorescent Protein and the constitutively active W539L point mutation of the mouse smoothened homolog (Drosophila) gene (SmoM2). Expression of the Smo/EYFP fusion gene is blocked by a loxP-flanked STOP fragment placed between the Gt(ROSA)26Sor promoter and the Smo/EYFP sequence. (J:89445)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Medullablastoma (J:139574)
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| References |
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Original: |
J:89445
Jeong J et al.,
"Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia."
Genes Dev 2004 Apr 15;18(8):937-51
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All: |
42 reference(s)
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Analysis Tools
