|
|
| Nomenclature |
|
Symbol:
|
Pgrtm2(cre)Lyd
|
|
Name:
|
progesterone receptor;
targeted mutation 2, John P Lydon
|
|
MGI ID: |
MGI:3576366 |
|
Synonyms: |
PRCre, PR-Cre |
|
Gene:
|
Pgr
Location:
Chr9:8900419-8965425 bp, + strand
Genetic Position: Chr9,
2.46 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:97321
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Cre recombinase cDNA was inserted into exon 1. An untranslated region was created immediately 5' of the cDNA by mutating the ATG codon for the B isoform to prevent an in-frame fusion from the N-terminal of the cre cDNA to the remaining 120 amino acids at the N-terminal end of the endogenous gene. A loxP-flanked neo was inserted 3' of the cre insertion. RNase protection analysis demonstrated that cre transcription was restricted to progestin target tissues, including the uterus, mammary gland and oviduct/ovary. (J:97321)
|
|
|
Recombinase activity
|
|
Driver:
|
Pgr
Summary of all recombinase alleles
driven by Pgr.
|
|
MGI has not yet included tissue activity data for this allele in any anatomical systems.
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Pgr Mutation:
|
6 strains or lines available |
|
| References |
|
Original: |
J:97321
Soyal SM et al.,
"Cre-mediated recombination in cell lineages that express the progesterone receptor."
Genesis 2005 Feb;41(2):58-66
|
|
All: |
37 reference(s)
|
|
Analysis Tools
