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| Nomenclature |
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Symbol:
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Ptgs1tm1Fun
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Name:
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prostaglandin-endoperoxide synthase 1;
targeted mutation 1, Colin D Funk
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MGI ID: |
MGI:3576237 |
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Synonyms: |
COX-1 KD, PGHS1Neo |
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Gene:
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Ptgs1
Location:
Chr2:36230426-36252272 bp, + strand
Genetic Position: Chr2,
24.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:97351
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A floxed PGK-neo was inserted into intron 10 to create this hypomorphic allele. Western blot showed that protein was dramatically reduced in mutant macrophages to approximately 10% of wild-type levels. (J:97351)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:97351
Yu Y et al.,
"Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition."
J Clin Invest 2005 Apr 1;115(4):986-995
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All: |
6 reference(s)
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Analysis Tools
