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| Nomenclature |
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Symbol:
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Nfe2l1tm1Jefc
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Name:
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nuclear factor, erythroid derived 2,-like 1;
targeted mutation 1, Jefferson Y Chan
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MGI ID: |
MGI:3574931 |
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Synonyms: |
Nrf1flox |
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Gene:
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Nfe2l1
Location:
Chr11:96817431-96829955 bp, - strand
Genetic Position: Chr11,
60.12 cM, cytoband D-E
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:97188
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Parent Cell Line:
| JM-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted into intron 3 and a loxP-flanked neo downstream exon 4. An IRES-GFP was at the 3' end of the neo. (J:97188)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nfe2l1 Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:97188
Xu Z et al.,
"Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia."
Proc Natl Acad Sci U S A 2005 Mar 15;102(11):4120-5
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All: |
2 reference(s)
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Analysis Tools
