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| Nomenclature |
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Symbol:
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Barx2tm1Rsd
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Name:
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BarH-like homeobox 2;
targeted mutation 1, Michael G Rosenfeld
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MGI ID: |
MGI:3574438 |
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Synonyms: |
Barx2- |
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Gene:
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Barx2
Location:
Chr9:31846097-31913462 bp, - strand
Genetic Position: Chr9,
17.25 cM
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Barx2tm1Rsd/Barx2tm1Rsd mice display open eyelids at birth, abnormal hair follicle remodeling and short whiskers and hair
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:96883
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A lacZ-PGK-neo replaced the 3' end of exon 2 and all of exon 3. The deleted sequence encoded the homeodomain and C-terminal sequence. RT-PCR of mutant skin samples demonstrated the loss of 3' message. The truncated transcript consisted of a 134 amino acid epitope fused in frame to Beta-galactosidase. (J:96883)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Barx2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:96883
Olson LE et al.,
"Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling."
Proc Natl Acad Sci U S A 2005 Mar 8;102(10):3708-13
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All: |
4 reference(s)
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Analysis Tools
