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| Nomenclature |
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Symbol:
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Spry1tm1.1Jdli
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Name:
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sprouty homolog 1 (Drosophila);
targeted mutation 1.1, Jonathan D Licht
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MGI ID: |
MGI:3574404 |
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Synonyms: |
Spry1- |
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Gene:
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Spry1
Location:
Chr3:37639947-37644598 bp, + strand
Genetic Position: Chr3,
18.46 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:96485
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Crossing Spry1tm1Jdli to cre deleter mice removed the entire coding sequence. RT-PCR of newborn kidney extracts demonstrated the absence of transcript in mutants. (J:96485)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Spry1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:96485
Basson MA et al.,
"Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction."
Dev Cell 2005 Feb;8(2):229-39
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All: |
15 reference(s)
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Analysis Tools
