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| Nomenclature |
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Symbol:
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Ightm1(Myc)Janz
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Name:
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immunoglobulin heavy chain complex;
targeted mutation 1, Siegfried Janz
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MGI ID: |
MGI:3574400 |
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Synonyms: |
iMycEmu |
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Gene:
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Igh
Location:
unknown
Genetic Position: Chr12,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:96785
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A His6-tagged Myc cDNA was inserted head to head into the locus 5' of the intronic enhancer Emu. This insertion of Myc mimics both the human t(8;14)(q24;q32) translocation that results in the activation of MYC in human endemic Burkitt lymphomas and the homologous mouse T(12;15) translocation that deregulates Myc in mouse plasmacytomas. (J:96785)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:96785
Park SS et al.,
"Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice."
Cancer Res 2005 Feb 15;65(4):1306-15
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All: |
9 reference(s)
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Analysis Tools
